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Author: search.filters.author.Mario Henríquez-BeltránResearch unit: search.filters.nucleo.Núcleo de Investigación en Ciencias de la Salud

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    Item type:Publication,
    Sleep health improvement trajectories after a pandemic: insights from a national health survey
    (2026)
    Jordi de Batlle
    ;
    Esther Gracia-Lavedan
    ;
    Adriano D S Targa
    ;
    Mario Henríquez-Beltrán
    ;
    Ferran Barbé
    <jats:title>Abstract</jats:title> <jats:sec> <jats:title>Study Objectives</jats:title> <jats:p>This study aimed to evaluate sleep health improvement trends in Catalonia, Spain, from 2020 to 2023 following the COVID-19 pandemic, and to identify disparities across demographic and socioeconomic groups.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>This repeated cross-sectional study analyzed 11 794 responses from eight waves of the Catalan Health Survey. Sleep health was assessed using the SATED and Ru-SATED questionnaires, covering six dimensions: Satisfaction, Alertness, Timing, Efficiency, Duration, and Regularity. Trends over time were evaluated, and stratified and interaction models assessed differences by sex, age, BMI, material deprivation, comorbidity burden, and living situation. Survey weights ensured population representativity.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Sleep health improved from mid-2021, then stabilized. Efficiency plateaued by late 2020, while Satisfaction remained the most unstable dimension. Sleep regularity diminished during the 2020 lockdowns but improved promptly afterward. Females consistently scored lower than males, though their improvement trajectories were similar (p-for-interaction = .906). Older adults (65+) and individuals with excess weight exhibited distinctive improvement trends (p-for-interaction = .023). Material deprivation was the strongest predictor of poor sleep health and delayed improvement (p-for-interaction = .024). Living alone had a temporary negative impact during lockdowns, which resolved by 2022. Finally, comorbidity burden affected baseline scores but not improvement trends (p-for-interaction = .467).</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusions</jats:title> <jats:p>Sleep health improvement post-pandemic was uneven across sleep dimensions and population subgroups. Behavioral sleep dimensions improved earlier, while subjective satisfaction lagged. Socioeconomic factors, particularly material deprivation, were strongly associated with poorer and slower improvements. These findings highlight the importance of incorporating sleep health into pandemic preparedness and tailoring interventions to address both behavioral and structural determinants of health.</jats:p> </jats:sec>
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    Item type:Publication,
    Skin advanced glycation end-products do not predict pulmonary function trajectories in adults from the ILERVAS cohort
    (2026)
    Gerard Torres
    ;
    Esther Gracia-Lavedan
    ;
    Jessica González
    ;
    Mario Henríquez-Beltrán
    ;
    Adriano D. S. Targa
    Advanced glycation end-products (AGEs) activate specific receptors (RAGE) promoting inflammation and oxidative stress. The lungs, with high RAGE expression, may be particularly susceptible to AGE-related injury. This study assessed whether baseline skin AGE levels, measured by skin autofluorescence (SAF), predict pulmonary function decline in middle-aged adults with cardiovascular risk factors. This ancillary analysis of the ILERVAS cohort included adults aged 45–70 years with cardiovascular risk factors but without diabetes or chronic kidney disease. Baseline data included demographics, lifestyle, and fasting blood tests. SAF was measured using AGE Reader™, and spirometry performed at baseline and after a median follow-up of 4 years. Associations between baseline SAF and annual declines in FEV1, FVC, and FEV1/FVC were analysed using adjusted models and generalized additive models, stratified by smoking status. Among 658 participants (median age 56 years, 48% female), median baseline SAF was 1.90 AU [1.60; 2.20]. Baseline lung function was preserved, with median FEV1, FVC and FEV1/FVC of 2795 mL [2270; 3,341], 3,525 mL [2870; 4300], and 78.6% [74.4; 82.8]. Annual declines were −  81.9 mL [− 120.6; − 43.3] for FEV1, − 99.6 mL [− 159.3; − 37.9] for FVC, and − 0.04% [− 0.85; 0.70] for FEV1/FVC. No significant associations were found between SAF and spirometry changes. Results were consistent across smoking subgroups. Baseline skin AGE levels did not predict pulmonary function decline over four years in middle-aged adults with cardiovascular risk factors. While SAF reflects cumulative AGE exposure, it has limited prognostic value for lung function in this population.